The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice

Hiroko Sonoda; Worapat Prachasilchai; Hiroaki Kondo; Naoko Yokota-Ikeda; Sayaka Oshikawa; Katsuaki Ito; Masahiro Ikeda

doi:10.1254/jphs.09259SC

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The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice

Hiroko Sonoda, Worapat Prachasilchai, Hiroaki Kondo, Naoko Yokota-Ikeda, Sayaka Oshikawa, Katsuaki Ito, Masahiro Ikeda

著者情報

キーワード: radicicol, renal ischemia–reperfusion injury, heat shock protein 70 kDa (HSP70)

ジャーナルフリー早期公開

論文ID: 09259SC

DOI https://doi.org/10.1254/jphs.09259SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 112 (2010) , No. 2 p.242

詳細

抄録

Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.

責任著者(Corresponding author)

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