Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

Takeshi Sakata; Naohiko Anzai; Toru Kimura; Daisaku Miura; Toshiyuki Fukutomi; Michio Takeda; Hiroyuki Sakurai; Hitoshi Endou

doi:10.1254/jphs.09331SC

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Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms

Takeshi Sakata, Naohiko Anzai, Toru Kimura, Daisaku Miura, Toshiyuki Fukutomi, Michio Takeda, Hiroyuki Sakurai, Hitoshi Endou

著者情報

キーワード: organic cation transporter, single nucleotide polymorphism, histamine

ジャーナルフリー早期公開

論文ID: 09331SC

DOI https://doi.org/10.1254/jphs.09331SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 113 (2010) , No. 3 p.263

詳細

抄録

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [³H]histamine and [³H]MPP⁺, although their protein expressions were detected in the plasma membrane of transfected cells. This study suggests that the OCT3 variants will contribute to inter-individual variations leading to the differences in cationic drug disposition as well as certain disease processes such as hypertension, allergic diseases, and neuropsychiatric diseases by the clearance of endogenous organic cations such as biogenic amines.

責任著者(Corresponding author)

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