Interactions of Human Organic Anion Transporters With Aristolochic Acids

Ellappan Babu; Michio Takeda; Ritsuo Nishida; Rie Noshiro-Kofuji; Masaaki Yoshida; Shiro Ueda; Toshiyuki Fukutomi; Naohiko Anzai; Hitoshi Endou

doi:10.1254/jphs.09339SC

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Interactions of Human Organic Anion Transporters With Aristolochic Acids

Ellappan Babu, Michio Takeda, Ritsuo Nishida, Rie Noshiro-Kofuji, Masaaki Yoshida, Shiro Ueda, Toshiyuki Fukutomi, Naohiko Anzai, Hitoshi Endou

著者情報

キーワード: aristolochic acid, organic anion transporter, aristolochic acid nephropathy

ジャーナルフリー早期公開

論文ID: 09339SC

DOI https://doi.org/10.1254/jphs.09339SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 113 (2010) , No. 2 p.192

詳細

抄録

Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA-II inhibited organic anion uptake by hOAT1, hOAT3, and hOAT4 in dose-dependent manners. Treatment of hOAT3 with AA-I resulted in a significant reduction in viability compared with that of mock, which was rescued by the organic anion transport inhibitor probenecid. In conclusion, hOAT3-mediated AA-I uptake may be associated with the induction of nephrotoxicity.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）