A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

Promsuk Jutabha; Naohiko Anzai; Keitaro Hayashi; Mariko Domae; Kohsuke Uchida; Hitoshi Endou; Hiroyuki Sakurai

doi:10.1254/jphs.10227SC

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A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

Promsuk Jutabha, Naohiko Anzai, Keitaro Hayashi, Mariko Domae, Kohsuke Uchida, Hitoshi Endou, Hiroyuki Sakurai

著者情報

キーワード: ochratoxin A, organic anion transporter, nephrotoxicity

ジャーナルフリー早期公開

論文ID: 10227SC

DOI https://doi.org/10.1254/jphs.10227SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 116 (2011) , No. 4 p.392

詳細

抄録

In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent uptake of OTxA (K_m: 802.8 μM) in a pH- and voltage-sensitive manner. Cis-inhibition experiments suggest that the substrate selectivity of hNPT4 is similar to that of hOAT4. The fact that the K_m of OTxA for the efflux transporter hNPT4 was much higher than those for the uptake transporters hOAT1 and hOAT3 may favor the accumulation of OTxA in the tubular cell and lead to nephrotoxicity.

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