Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells

Toru Oda; Toshiaki Kume; Yasuhiko Izumi; Kumatoshi Ishihara; Hachiro Sugmimoto; Akinori Akaike

doi:10.1254/jphs.11011SC

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Na⁺/Ca²⁺ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells

Toru Oda, Toshiaki Kume, Yasuhiko Izumi, Kumatoshi Ishihara, Hachiro Sugmimoto, Akinori Akaike

著者情報

キーワード: Na⁺/Ca²⁺ exchanger (NCX), neurite outgrowth, PC12

ジャーナルフリー早期公開

論文ID: 11011SC

DOI https://doi.org/10.1254/jphs.11011SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 116 (2011) , No. 1 p.128

詳細

抄録

To elucidate the role of Na⁺/Ca²⁺ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3′,4′-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho–ROCK signal transduction pathways in neurite outgrowth.

責任著者(Corresponding author)

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