Abstract
The distribution of γ-aminobutyric-α-ketoglutaric acid transaminase and DPN-linked succinic semialdehyde dehydrogenase in 7 areas of rat brain was determined. Both enzyme activities vary with the age of the animal. The activity of both enzymes in the different brain areas roughly parallels the concentration.
Estimations of enzyme activity in various parts of the brain taken from animals pretreated with either pentobarbital, diphenylhydantoin or trimethadione show a depression of activity of both enzymes the extent of which vary in different parts. The drugs in concentrations which are present in the brain when added to the enzymes in vitro do not inhibit them.
