Abstract
In recent years there have been a great number of compounds synthesized for their atropine-like effect. Recently a new class of compounds, derivatives of 3-diphenylmethylene-pyrrolidine, has been synthesized by Ohki et al., some of which have been found to possess potent anticholinergic activity (1). Studies of the relationship between the chemical structure and anticholinergic and antihistaminic activities in vitro of these compounds have been carried out and 1, 1-diethyl-2-methyl-3-diphenylmethylenepyrrolidinium bromide (Pyrodifenium bromide: hereinafter referred to as PDB), a quaternary ammonium compound, has been found to possess the most potent anticholinergic activity among these mentioned derivatives (2). In this report, the authors carried out pharmacological studies of this compound on its peripheral anticholinergic action in comparison with atropine, and on ganglion blocking, neuromuscular blocking and central nervous system actions. The chemical structure of this compound is shown in Fig. 1.
