THE ANTISCORBUTIC ACTIVITY OF L-ASCORBIC ACID PHOSPHATE GIVEN ORALLY AND PERCUTANEOUSLY IN GUINEA PIGS

Abstract

Cutolo and Larriza (1) synthesized 3-phosphoryl-L-ascorbic acid, and they noted that some amount of the compound was excreted as ascorbic acid (AsA) in the guinea pig urine after oral or intraperitoneal administration, however, its antiscorbutic activity is not yet estimated. The authors studied the antiscorbutic activity of the compound as well as its percutaneous absorption in guinea pigs.