Abstract
Since earlier studies with nalorphine in humans demonstrated analgesia (1, 2) without producing dependence of the morphine type (1-3), a considerable effort has been made to discover a drug having similar characteristics, but without undesirable psychic effects. Pentazocine was found to be in this category (4-7).
Recently, 1-(m-methoxyphenyl)-2-dimethylaminomethyl cyclohexanol (1) HCl (hereafter referred to as CG-315) was synthesized as a new central analgesic, by Grünenthal Co., Ltd., West Germany. Henmi et al. (8, 9) demonstrated that analgesic action of CG-315 is similar to that of dihydrocodeine and also potentiates the response to adrenaline of nictitating membrane and cardiovascular organs in cats. Experiments were carried out to evaluate the physical dependence liability in rats.
