The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM)
3RD REPORT : NEM INDUCED HYPERGLYCEMIA IN RATS
Hiroyuki YAMAMOTOYasusuke MASUDANobuyuki OKADATadashi MURANO
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JOURNAL FREE ACCESS

1973 Volume 23 Issue 2 Pages 167-175

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Abstract
Intraperitoneal injection of NEM to rats, produced marked hyperglycemia, a considerable decrease in liver glycogen and inhibition of glucose uptake in skeletal muscles. It is postulated that these phenomena are due to the acceleration of sugar mobilization from liver glycogen, inhibition of glucose utilization in peripheral organ tissues, and partial mediation of epinephrine released from adrenal medulla. NEM reacted quickly with red cells but not with plasma protein and was inactivated or taken up into red cells, the reason being that when NEM is administered i.v. the action is much weaker.
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© The Japanese PharmacologicalSociety
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