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Volume 23 (1973)
- Issue 6 Pages 753-
- Issue 5 Pages 599-
- Issue 4 Pages 431-
- Issue 3 Pages 277-
- Issue 2 Pages 129-
- Issue 1 Pages 1-
Volume 23, Issue 2
Displaying 1-18 of 18 articles from this issue
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Hiroyuki YAMAMOTO, Yasusuke MASUDA, Hiroaki FURUTA, Zenichi HENMI, Tad ...1973 Volume 23 Issue 2 Pages 129-139
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSSubcutaneously or per orally administered CG-315 was rapidly absorbed and widely distributed in rat whole body, especially in the lungs, spleen, liver and kidneys etc. Most of the administered drug and its metabolites was excreted in the urine within 24 hr with a small amount in the feces. Part of absorbed CG-315 may be mainly metabolized in liver to O-, N- or both demethylated forms, some of which are conjugated with glucuronates. No difference was found in metabolism of CG-315 between non-tolerant and tolerant rats.View full abstractDownload PDF (1058K) -
(1) LEAKAGE OF NADH-CYTOCHROME c REDUCTASE INTO PLASMA FROM LIVER CELLS IN CCl4-POISONED RATSHiroyuki YAMAMOTO, Masato KUCHII, Yasusuke MASUDA, Tadashi MURANO1973 Volume 23 Issue 2 Pages 141-150
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSNADH-cytochrome c reductase was not observed in normal rat plasma. NADH-cytochrome c reductase appeared in the plasma of rats after CCl4 administration. The time-course pattern of the enzyme activity was quite different between the sexes, and the elevation of the activity was markedly enhanced by fasting. NADH-cytochrome c reductase activity detected in the circulating plasma of CCl4- poisoned rats originated from the microsomal NADH-cytochrome b5 reductase system in liver cells. Mechanisms of the leakage of this enzyme into the plasma are discussed.View full abstractDownload PDF (1001K) -
1ST REPORT : INFLUENCE OF NEM ON SYNAPTIC TRANSMISSION OF SYMPATHETIC NERVES IN GUINEA PIGSHiroyuki YAMAMOTO, Takafumi KITANO, Hitoo NISHINO, Tadashi MURANO1973 Volume 23 Issue 2 Pages 151-160
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSIn isolated guinea pig atrial preparations, NEM in the concentration of 5×10-5 M to 10-4 M produced an increase in the amplitude and rate of contraction at earlier stages, resulting in inhibition of contraction accompanied by an increase in resting tension and irregularity in rate at later stages, while the diphasic actions of NEM were completely antagonized by cysteine. The initial action of NEM was blocked by propranolol, guanethidine and failed to appear in the reserpinized atria, but reappeared after incubation of atria with norepinephrine indicating that it is mediated by norepinephrine. NEM augmented the contractile response of ductus deferens to hypogastric nerve stimulation at the earlier stages, but suppressed it at later stages. The augmenting effect of NEM on the response to sympathetic nerve stimulation was dependent on calcium concentrations in suspending medium. Effects of NEM on synaptic transmission of sympathetic nerves were discussed.View full abstractDownload PDF (3703K) -
2ND REPORT : AN INFLAMMATORY PROPERTY OF NEM IN RATSHiroyuki YAMAMOTO, Nobuyuki OKADA, Ichiro YANO, Tadashi MURANO1973 Volume 23 Issue 2 Pages 161-166
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSNEM administered i.p. produced apparent accumulation- of exudative ascites, followed by an increase in hematocrit values and neutrophilia in differential leukocytes counts. Dilatation of vascular capillaries together with hyperemia, scattered foci of perivascular infiltration of monocytes and precipitation of fibrin in mesentery were histologically observed after administration of NEM. These phenomena were not observed in the liver. NEM, when intracutaneously administered, resulted in obvious edema in rat hind paw with a marked increase in capillary permeability. The inflammatory action of NEM was completely blocked by cysteine, but not by cortisone or indomethadine, suggesting that NEM induced edema results from the reaction with selective SH groups in tissues.View full abstractDownload PDF (5294K) -
3RD REPORT : NEM INDUCED HYPERGLYCEMIA IN RATSHiroyuki YAMAMOTO, Yasusuke MASUDA, Nobuyuki OKADA, Tadashi MURANO1973 Volume 23 Issue 2 Pages 167-175
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSIntraperitoneal injection of NEM to rats, produced marked hyperglycemia, a considerable decrease in liver glycogen and inhibition of glucose uptake in skeletal muscles. It is postulated that these phenomena are due to the acceleration of sugar mobilization from liver glycogen, inhibition of glucose utilization in peripheral organ tissues, and partial mediation of epinephrine released from adrenal medulla. NEM reacted quickly with red cells but not with plasma protein and was inactivated or taken up into red cells, the reason being that when NEM is administered i.v. the action is much weaker.View full abstractDownload PDF (2607K) -
Kohei NISHIKAWA, Shintaro KIKUCHI1973 Volume 23 Issue 2 Pages 177-187
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSInvolvement of the adrenergic mechanism in the diuretic action of o-chloro-benzyl methyl sulfoxide (DS-30) was investigated in the rat. Norepinephrine and metaraminol induced diuresis, which was blocked by pretreatment with tolazoline. Isoproterenol induced antidiuresis, which was blocked by pretreatment with propranolol. The diuretic effect of DS-30 as well as that of epinephrine was reversed by pretreatment with tolazoline, but not with propranolol. The diuretic action of hydrochlorothiazide and furosemide was not influenced by pretreatment with tolazoline. The diuretic effect of DS-30 was not affected by reserpinization of rats.View full abstractDownload PDF (1295K) -
Shigetoshi CHIBA, Katsunori OGURO, Koroku HASHIMOTO1973 Volume 23 Issue 2 Pages 189-194
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSUsing in situ constant pressure perfusion of the SA node artery at 100 mmHg, the effect of thymoxamine, which is a salt of (6-acetoxythymoxy) ethyldimethylamine, was investigated in 7 vagotomized dogs weighing 9 to 15 kg. Thymoxamine injected into the SA node artery induced a biphasic chronotropic response, i.e. a deceleration of sinus rate followed by an acceleration. The threshold dose for induction of sinus deceleration by thymoxamine was 3 to 10 μg. This deceleration response was not influenced by atropine treatment. The threshold dose for induction of sinus acceleration by thymoxamine was 10 to 30 μg. This accelerated response was inhibited by propranolol or tetrodotoxin. These results indicate that thymoxamine induces direct depressive action on the SA node pacemaker and the acceleration due to catecholamine release accompanying excitation of sympathetic nerve fibers in the SA node region.View full abstractDownload PDF (633K) -
K. N. GARG, S. SHARMA, S. BALA1973 Volume 23 Issue 2 Pages 195-200
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSIn the present investigation the action of sparteine sulphate alone and in combination with other drugs has been studied on isolated human uterine strips, from both pregnant and non-pregnant uteri. The effect of sparteine sulphate alone has been found to be dose dependant. Out of various combinations stilbesterol and priscol made a good combination for clinical use, however, further clinical studies on these combinations are indicated.View full abstractDownload PDF (729K) -
lST REPORT : ELECTRON MICROSCOPIC STUDIES ON THE ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA IN THE CELLS OF ZONA FASCICULATA OF THE ADRENAL CORTEX IN MORPHINE ADDICTED RATSIchiro YANO, Hitoo NISHINO, Hiroyuki YAMAMOTO, Tadashi MURANO1973 Volume 23 Issue 2 Pages 201-215
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSInfluence of morphine on the fine structure of mitochondria in the cells of zona fasciculata in rat adrena 1 cortex was studied electronmicroscopically. By the administration of morphine to rats in a dose of 20 mg/kg, the specific honeycomb like structure of mitochondria in adrenocortical cells was observed to be transformed from vesicular forms into tubulo-vescicular or tubular ones, while the changed structure gradually diminished during repeated administration of the drug. Withdrawal of morphine caused an extensive re-transformation, while with a reinjection of the drug, a prompt restoration to the pretreated structure was observed. The feasibility of utilizing this transformation as an index of physical dependence liability has been discussed.View full abstractDownload PDF (28583K) -
2ND REPORT : RELATIONSHIP BETWEEN TRANSFORMATION OF INTRAMITOCHONDRIAL STRUCTURES IN ADRENOCORTICAL CELLS AND CORTICOSTERONE BIOSYNTHESIS IN MORPHINE ADDICTED RATSHiroyuki YAMAMOTO, Shinji MIKITA, Ichiro YANO, Yasusuke MASUDA, Tadash ...1973 Volume 23 Issue 2 Pages 217-225
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSInfluence of morphine on the transformation of intramitochondrial structure in rat adrenocortical cells and the response of isolated adrenals to ACTH in corticosterone biosynthesis was comparatively studied. Administering morphine 20 mg/kg to rats, the decrease in the sensitivity of cortical cells to ACTH in steroidogenesis was observed to be parallel in time to the onset of transformation of mitochondria, while withdrawal of morphine in addicted rats resulted in a similar change. Re-administration of morphine to the withdrawn rats caused nearly complete recovery to the original state within a few hr of both mitochondrial structure and sensitivity to ACTH.View full abstractDownload PDF (1016K) -
3RD REPORT : ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN A NEW ANALGESIC, CG-315 CHRONICALLY ADMINISTERED RATSIchiro YANO, Hitoo NISHINO, Yasusuke MASUDA, Hiroyuki YAMAMOTO, Tadash ...1973 Volume 23 Issue 2 Pages 227-231
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSCG-315, an analgesic which formed no physical dependence in our experiments was incapable of inducing the transformation of intramitochondrial structure in adrenocortical cells after abrupt withdrawal of the drug in chronically administered rats in contrast to that in morphine addicted rats.View full abstractDownload PDF (8982K) -
Kuniomi TACHIBANA, Hisatoshi KABENO, Yasuaki KOBAYASHI1973 Volume 23 Issue 2 Pages 233-242
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSEffects of TG on intestinal smooth muscle were examined using isolated guinea-pig ileum and for the effects on gastric secretion Schild's rats were used. Stimulant actions of TG on guinea-pig ileum may be indirect, that is, the stimulation of postganglionic parasympathetic nerves, leading to the release of acetylcholine. Gastric secretion stimulating action of TG on Schild's rats may be direct action to the oxyntic glands and it may be not mediated by released acetylcholine or histamine.View full abstractDownload PDF (991K) -
Shunkichi TAMURA, Shintaro TSUZUKI, Shinitsu SHOJI, Kenichi AKATSUKA, ...1973 Volume 23 Issue 2 Pages 243-250
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSP3 and P4 substances were collected from fresh urine of normal male subjects by the techniques of saturation with acetone and precipitation with lead acetate. In addition, FII was fractionated out chromatographically from P3, and was found to have a strong activity in producing cardiac arrest in the frog. It was possible to obtain evidence that the activity of FII is the essence of that of P3 and that FII consists of a single or nearly single substances as chromatographically shown. FII fraction appears to be a peptide of low molecular weight with lysine and tyrosine among the constituents. P4 had no such activity as FII or P3 but suggested the glucoside-type bond. Treatment with acids and heat showed that P4 originates from the same substances as glucuronic acid. Partial hydrolysis of FII resulted in two different ninhydrin-positive components in addition to lysine and tyrosine. Two ninhydrin-positive substances were found among the partial hydrolytes of P4. It is suggested that there is a resemblance in basic structure between FII and P4.View full abstractDownload PDF (4344K) -
Takashi BAN1973 Volume 23 Issue 2 Pages 251-258
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSThe antagonistic effects of two new β-receptors blocking agents, Kö 1313 and Kö 1366 against the chronotropic and inotropic responses to noradrenaline and tyramine were studied on the isolated right and left atria of guinea-pigs. From the KB values estimated by means of three different methods, it was found that the potencies of Kö 1366 were 5 to 10 times and 5 to 7 times those of Kö 1313 in the antagonism against chronotropic and inotropic effects of noradrenaline respectively. From the depression of maximum chronotropic and inotropic effects of tyramine in the presence of these agents, Kö 1366 was demonstrated to be approx. three times more potent than Kö 1313 in the antagonism against both effects of tyramine.View full abstractDownload PDF (930K) -
O. D. GULATI, B. P. METHEW, H. M. PARIKH, V. S. R. KRISHNAMURTY1973 Volume 23 Issue 2 Pages 259-268
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSIsolated aortic strips from rabbits older than 6 months (1.7-2.5 kg) when subjected to contraction by noradrenaline or adrenaline were relaxed by isoprenaline. The relaxation was not blocked by propranolol. When these strips were contracted by potassium chloride, isoprenaline produced a small relaxation which was sensitive to propranolol. In aortic strips from rabbits 2-3 months old (0.75-0.95 kg), the contraction produced by noradrenaline or potassium chloride was relaxed by isoprenaline; isoprenaline was equally active against both stimulants. Propranolol antagonised the action of isoprenaline competitively, with a pA2 value, 7.05. In strips from rabbits from a lower age group, the pA2 values of phentolamine against isoprenaline and methoxamine contractions were 7.61 and 7.50 respectively. It is concluded that aortas of rabbits older than 6 months are almost devoid of beta adrenergic receptors whereas those of rabbits 2-3 months old contain both alpha and beta adrenergic receptors.View full abstractDownload PDF (2297K) -
A. K. CHATTERJEE, S. K. DIGHE, R. C. NAITHANI, A. S. SACHAN, Bal KRISH ...1973 Volume 23 Issue 2 Pages 269-271
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSDownload PDF (400K) -
PART 1. EEG STUDIES IN RABBITSToshiharu OHGOH, Kazuo TANAKA1973 Volume 23 Issue 2 Pages 271-273
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSDownload PDF (400K) -
Katsumi NAITO, Kinya KURIYAMA1973 Volume 23 Issue 2 Pages 274-276
Published: April 01, 1973
Released on J-STAGE: March 23, 2011
JOURNAL FREE ACCESSDownload PDF (370K)
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