The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS
lST REPORT : ELECTRON MICROSCOPIC STUDIES ON THE ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA IN THE CELLS OF ZONA FASCICULATA OF THE ADRENAL CORTEX IN MORPHINE ADDICTED RATS
Ichiro YANOHitoo NISHINOHiroyuki YAMAMOTOTadashi MURANO
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1973 Volume 23 Issue 2 Pages 201-215

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Abstract
Influence of morphine on the fine structure of mitochondria in the cells of zona fasciculata in rat adrena 1 cortex was studied electronmicroscopically. By the administration of morphine to rats in a dose of 20 mg/kg, the specific honeycomb like structure of mitochondria in adrenocortical cells was observed to be transformed from vesicular forms into tubulo-vescicular or tubular ones, while the changed structure gradually diminished during repeated administration of the drug. Withdrawal of morphine caused an extensive re-transformation, while with a reinjection of the drug, a prompt restoration to the pretreated structure was observed. The feasibility of utilizing this transformation as an index of physical dependence liability has been discussed.
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© The Japanese PharmacologicalSociety
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