STUDIES ON THE FUNCTION OF CELL MEMBRANE

9TH REPORT: PROTECTIVE ACTION OF SODIUM TAURINE N-CARBO-DITHIOATE (TDT) AGAINST CCl₄-INDUCED BIOCHEMICAL CHANGES IN LIVER CELL MEMBRANE OF RATS

Abstract

TDT alone showed no significant effect on NADH-cytochrome c reductase or ATPase activity in liver cell membrane or microsomes. TDT completely repressed alteration of these enzyme activities in the membrane as well as leakage of the reductase into plasma resulting from CCl₄ administration. TDT did not vary either the normal or the lowered body temp. resulting from an injection of CCl₄. Mechanism of action of TDT was discussed.