EFFECTS OF AN ANTIULCER AGENT, N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX (KW-110) ON THE DUODENAL AND GASTRIC ULCER MODELS IN THE RAT

Abstract

Antiulcer effects of N-acetyl-L-glutamine aluminum complex (KW-110) were studied in experimental gastric and duodenal ulcer models in the rat, comparing its effect to that of atropine sulfate. It was found that KW-110, given orally 3 times daily for 8 days, had an accelerating activity on the healing process of duodenal ulcer whereas atropine sulfate, given s.c. twice daily for 8 days at a glutamine dose to Sufficiently suppress gastric secretion, had a significant effect. In addition, KW-110 showed remarkable effects on prevention of acutely induced experimental gastric ulcers. In regard to the Shay ulcer or aspirin-induced gastric lesions, KW-110 showed enhanced effects which exceeded the apparently maximum effects of atropine sulfate, even though the dosage of the former was much higher than that of the latter. While atropine sulfate completely inhibited the stress-induced gastric lesions, KW-110 also revealed a strong inhibition on the lesions.