Abstract
Interaction between early and delayed phases in developmental process of hind paw swelling was investigated in rats using the mixed phlogistics-induced paw edema technique. Swelling induced by a mixture of carrageenin and Kaolin was observed in both the early and delayed phases. Despite of the augmentation of the early phase induced by the mixture, the delayed phase was not altered. The delayed phase was not reduced by treatment with antihistaminics and/or anti-serotonin agents, whereas the early phase was inhibited with those agents. The delayed phase was inhibited with anti-inflammatory agents without alterating the early phase. The potentiating effect on the delayed phase was observed in the combined use of flufenamic acid and diphenhydramine. From these results, it is concluded that the delayed phase is independent from the early phase in the developmental process of hind paw edema, but it is related to the early phase in chemotherapy. Furthermore, effects of various agents on the mixed phlogistics-induced hind paw edema, the some of which included 0.1 % histamine, 0.01 % serotonin, 0.5 % carrageenin and 5 % Kaolin were investigated by localized and oral application and are discussed herein.
