The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
EFFECTS OF ACETYLCHOLINE RELEASING DRUGS ON ELECTRICAL ACTIVITIES OBTAINED FROM AUERBACH'S PLEXUS IN THE GUINEA PIG ILEUM
Takao SATOIssei TAKAYANAGIKeijiro TAKAGI
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ジャーナル フリー

1974 年 24 巻 3 号 p. 447-451

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抄録
Effects of 5-hydroxytryptamine, sodium picrate, caerulein and pentagastrin on the electrical activities obtained from Auerbach's plexus in the guinea pig ileum were investigated. The drugs used increased the spike frequency and increase of the spike frequency induced was inhibited by morphine but not by atropine and hexamethonium. The muscle spikes obtained simultaneously were inhibited by atropine. These facts indicate that the drugs used stimulate Auerbach's plexus and accelerate the acetylcholine release from the cholinergic post-ganglinoic nerve endings. The sites of action of morphine are also discussed.
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© The Japanese PharmacologicalSociety
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