PHARMACOKINETIC STUDIES ON THE HEPATOTOXICITY OF LUTEOSKYRIN. (1) INTRACELLULAR DISTRIBUTION OF RADIOACTIVITY IN THE LIVER OF MICE ADMINISTERED 3H-LUTEOSKYRIN

Ikuko UENO; Tomiko HAYASHI; Yoshio UENO

doi:10.1254/jjp.24.535

The Japanese Journal of Pharmacology

Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198

PHARMACOKINETIC STUDIES ON THE HEPATOTOXICITY OF LUTEOSKYRIN. (1) INTRACELLULAR DISTRIBUTION OF RADIOACTIVITY IN THE LIVER OF MICE ADMINISTERED ³H-LUTEOSKYRIN

Ikuko UENO, Tomiko HAYASHI, Yoshio UENO

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1974 Volume 24 Issue 4 Pages 535-542

DOI https://doi.org/10.1254/jjp.24.535

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Abstract

Intracellular distribution of the radioactivity derived from ³H-luteoskyrin in mouse liver was investigated. It was revealed that luteoskyrin has a high affinity to mitochondria and cell debris of mouse liver cells. This characteristic distribution pattern in the liver cells may be responsible for the mitochondrial impairment and the age and sex differences in the susceptibility of mice to this mycotoxin.

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