The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
2α, 3α-EPITHIO-5α-ANDROSTAN-17β-YL 1-METHOXY CYCLOPENTYL ETHER (10364-S), A NEW ORALLY ACTIVE ANABOLIC-ANDROGENIC STEROID
Tamotsu MIYAKEKiyohisa UCHIDAHisato KAKUSHIYasuharu NOMURAMasumi KADOWAKIKenji MIYATATomoyuki HANAFUSARi-ichi MURANAKA
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1974 Volume 24 Issue 4 Pages 551-558

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Abstract

2α, 3α-Epithio-5α-androstan-17β-yl l-methoxycyclopentyl ether (10364-S) was found to possess marked myotropic and androgenic activities by oral route in the rat, and its potency and myotropic-androgenic ratio were estimated to be almost equivalent to those of fluoxymesterone. It was further demonstrated that the oral administration of 10364-S, 20 mg/kg a day for 3 weeks, had hardly no effect on liver function of rabbits tested by BSP retention, plasma GOT and GPT activities, and plasma cholesterol levels, whereas treatment with methyltestosterone, oxymetholone or fluoxymesterone, at the same dosage, caused abnormal BSP retention and plasma GOT activity. It is thus concluded, that 10364-S when given orally is an active anabolic agent with a therapeutic potency equivalent to fluoxymesterone yet in clinical administration is less likely to cause hepatic disturbance.

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