ANTIULCEROGENIC PROPERTY OF SODIUM POLYACRYLATE ON EXPERIMENTAL ULCERATIONS IN RATS

Abstract

The antiulcerogenic properties of sodium polyacrylate (PAS) against experimental ulcerations in rats were studied and compared with amylopectin sulfate (APS). Intragastric administration of PAS or APS to the pylorus ligated rat reduced ulceration. The protective effects of both drugs were dose dependant and PAS was less effective than APS. The gastric lesion induced by reserpine was inhibited by the oral ingestion of PAS mixed with sugar, while APS had no protective effect. More ingesta were found in the stomachs of the PAS group than the APS or control groups. PAS was confirmed to be an inhibitor of pepsin in vitro, but less effective than APS. Although PAS had little effect on the secretory volume of the gastric juice of the 6 hr pylorus ligated rat, it did cause a reduction of free acid in the juice. PAS did not possess anticoagulant activity.