Abstract
An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric mucosa in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dosedependent. Stress itself (23°C, 7 hr) did not induce any appreciable changes in gastric mucosa of rats. L-glutamine, given together with ASA or TCA, significantly prevented the potentiated development of ASA- or TCA-induced gastric lesions in stressed rats. L-glutamine also prevented in varying degrees the reduction of acid and increment of Na+ ion in gastric juice accumulated in stressed rats in response to ASA or TCA.
