EFFECTS OF NICOTINAMIDE AND INSULIN ON GLYCOSYLATED HEMOGLOBIN AND BLOOD GLUCOSE IN THYROIDECTOMIZED STREPTOZOTOCIN-DIABETIC RATS

Abstract

The present study deals with the effects of nicotinamide and insulin on glycosylated hemoglobin (HbA₁) and blood glucose in thyroidectomized streptozotocin (STZ)-diabetic male rats. Nicotinamide (500 mg/kg body wt., i.p.) significantly decreased the levels of HbA₁ and blood glucose in both STZ-treated (65 mg/kg body wt., i.v.) intact and STZ-treated thyroidectomized animals. Administration of NPH-insulin recovered hyperglycemia, and the increased HbA₁ in thyroidectomized STZ-diabetic rats to control levels.