Structural Biology of Prostaglandin Receptors

Abstract

Prostaglandins (PGs), lipid mediators, exert various effects in vivo through receptor-mediated signal transduction, and the elucidation of the molecular mechanisms of signal transduction by structural biology of PG receptors is expected to contribute to drug discovery. We have elucidated the molecular mechanisms of ligand binding mode, signal transduction mechanism, and G protein selectivity through structural analysis of PG receptors. In this paper, we would like to introduce the structure and function of GPCRs revealed through structural biology of PG receptors.