PHARMACOLOGICAL STUDIES ON COUGH REFLEX

PART 3. “COUGHING DOG” AND ITS APPLICATION

抄録

I gave out two methods (1) for evaluation of the effects of antitussives. In the initial stage of my experiment the cough attacks were induced in an unanesthetized dog either by mechanically stimulating with a bristled stimulator the mucous membranes of the tracheal bifurcation (method 1) or by electrically stimulating the ramus trachealis nervi laryngici cranialis (method 2). However, the bloody surgical procedures required in either method made it impossible to use the same dog in a series of experiments or to continue the daily administration of an antitussive over a long period of time for observation of possible changes in its effects. Accordingly, the methods have since been so improved as to make a continuous use of one and the same dog possible. The improved method, though the same in principle as method 1, differs from it in that the mechanical stimulation of the-tracheal bifurcation is given by a bristled stimulator through a cannula inserted into a tracheal fistula surgically produced prior to the experiment.