THE EFFECT OF ANALGESICS ON THE SPINAL REFLEX ACTIVITY OF THE CAT
1955 年 4 巻 2 号 p. 176-187
詳細
1955 年 4 巻 2 号 p. 176-187
During recent years the electrical phenomena associated with spinal reflex functions have been recorded by means of electrodes placed on the ventral and dorsal roots or on the dorsal cord.
The physiological significance of these electrical phenomena has been determined to a certain extent by neurophysiologists.
More recently, Magoun and his associates (1, 2, 3) found that. the reticular formation of the brain stem has descending inhibitory and facilitatory influences upon the spinal reflex activity.
The electrophysiological study of the effect of morphine on the spinal reflex has been reported by Wikler (4), but its effect on the reticular formation of the brain stem remains to be investigated.
The precise analysis concerning the sites of action of analgesics on the various afferent pathways of pain has been performed by Fujita et al. (5, 6) in our laboratory. The effects of these drugs on the spinal reflexes, however, are not yet sufficiently settled.
The purpose of the present investigation is to obtain further information respecting the effect of some analgesics and related drugs on the reflex activity of the spinal cord, and to trace the relationship between their effect and the function of reticular formation of the brain stem.
