Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig

Abstract

Protective effect of α-human atrial natriuretic peptide (α-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of α-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 μg of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of α-hANP was considered to be receptor mediated because the effective concentration was close to the K_d value of the binding of the ANP receptors in the lung homogenate.