Isoproterenol-Induced Facilitation of Norepinephrine Release Does Not Primarily Involve a Local Angiotensin II Mechanism in Guinea Pig Pulmonary Arteries

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We have attempted to clarify whether or not captopril and ¹Sar-⁸lle-angiotensin II could protect isoproterenol-induced facilitation of norepinephrine release in guinea pig pulmonary arteries loaded with ³H-norepinephrine. Angiotensin I at 1 nM and 30 nM isoproterenol similarly facilitated evoked release of ³H-norepinephrine at 1 Hz. Captopril at 1 μM and ¹Sar-⁸lle-angiotensin II at 10 nM completely prevented angiotensin I-induced facilitation, whereas these pretreatments produced no effect on isoproterenol-induced facilitation. Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism.