Nitroarginine Inhibits Endothelium-Derived Relaxation

抄録

Effects of N^G-nitro-L-arginine (NO ₂Arg), a guanidinonitro arginine derivative, on acetylcholineinduced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO₂Arg dose-dependently and the maximum relaxation with 10 μM NO₂ Arg was reduced to 10.1±4.3% (n=5). L-arginine (10 μM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO₂Arg. These results indicate that NO2Arg is a novel inFiibitor of endothelium-derived relaxation.