Effect of Bifemelane Hydrochloride on an Injury of the Liver Caused by Ischemia-Reperfusion in Rats

抄録

In the liver ischemia-reperfusion model, the lipid peroxide level increased during ischemic periods, while a greater increase was observed during reflow periods. The increase in the cytochrome b₅ content was observed during ischemia and reflow periods. On the contrary, the cytochrome P-450 content remained unchanged during ischemic periods, but decreased during reflow periods. Bifemelane suppressed the elevation of the lipid peroxide level, the cytochrome b₅ content and the decrease in cytochrome P-450 content during the period of reperfusion.