Conversion of ³H-Nitrendipine Binding to the Low Affinity Binding State Following the Treatment of Hippocampal Slices with Morphine

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The effect of morphine on the binding of ³H-nitrendipine was studied in rat hippocampal preparations. Treatment of slices with morphine followed by the preparation of membrane fractions revealed the presence of low affinity binding sites. The effect of morphine was antagonized by naloxone. The effect was not observed when the membrane fraction was incubated with morphine. These results suggest that morphine changes the affinity of calcium for its channels and reduces its influx.