A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria

Lei-Ming Ren; Yasuyuki Furukawa; Yasuyuki Karasawa; Makoto Murakami; Shin Takayama; Yasurou Inoue; Shoji Sawaki; Shigetoshi Chiba

doi:10.1254/jjp.57.613

Lei-Ming Ren, Yasuyuki Furukawa, Yasuyuki Karasawa, Makoto Murakami, Shin Takayama, Yasurou Inoue, Shoji Sawaki, Shigetoshi Chiba

著者情報

ジャーナルフリー

1991 年 57 巻 4 号 p. 613-616

DOI https://doi.org/10.1254/jjp.57.613

詳細

抄録

Using an isolated, blood-perfused canine atrial preparation, we investigated the effects of omega-conotoxin GVIA (omega-CgTX), a blocker of N-type voltage-operated calcium channels, on the atrial contractile force and sinus rate. Omega-CgTX in a dose range of 0.3-3 nmol gradually attenuated the atrial contractile force in a dose-dependent manner, but did not affect the sinus rate, indicating that it can depress contractility but not pacemaker activity.

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