Inhibitory Effects of 7-OH-DPAT, Dopamine D3-Receptor Agonist, on Nucleus Accumbens Neurons

Taku Amano; Hiroaki Matsubayashi; Toshihiko Momiyama; Masashi Sasa

doi:10.1254/jjp.65.293

Inhibitory Effects of 7-OH-DPAT, Dopamine D₃-Receptor Agonist, on Nucleus Accumbens Neurons

Taku Amano, Hiroaki Matsubayashi, Toshihiko Momiyama, Masashi Sasa

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Keywords: 7-Hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT), Dopamine D₃ receptor, Electrophysiology

JOURNAL FREE ACCESS

1994 Volume 65 Issue 3 Pages 293-295

DOI https://doi.org/10.1254/jjp.65.293

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Abstract

Effects of 7-hydroxy-2-(N, N-di-n-propylamino)tetralin (7-OH-DPAT), a dopamine D₃-receptor agonist, on neuronal activities of the nucleus accumbens (Acc) were examined in chloral hydrate-anesthetized rats. Spikes elicited by stimulation of the parafascicular nucleus were dose-dependently inhibited by microiontophoretic application of dopamine and 7-OH-DPAT. Glutamate-induced firing was also inhibited by these drugs. These findings suggest that D₃ receptors are also involved in the postsynaptic inhibition of Acc neuron by dopamine.

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