Novel Dolichyl Derivatives in Rat Spleen

Abstract

  Novel dolichyl derivatives were found in rat spleen. The compounds were eluted from reverse phase HPLC after eluting dolichyl fatty acid ester. The elution profiles of the unsaponified forms of the unknown compounds were coincident with that of dolichol from spleen on reverse phase HPLC. The compounds were not dolichyl dolichoate, which are present in bovine thyroid. The compounds were not found in young rats (4 months of age) but were found in old rats (above 12 months of age), and they were not detected in other tissues under our conditions.