Histological Evidence for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive

Mihoko N. Nakashima; Yasufumi Kataoka; Kimihiro Yamashita; Masami Kohzuma; Masataka Ichikawa; Masami Niwa; Yasuko Kohno; Kohtaro Taniyama

doi:10.1254/jjp.67.91

Mihoko N. Nakashima, Yasufumi Kataoka, Kimihiro Yamashita, Masami Kohzuma, Masataka Ichikawa, Masami Niwa, Yasuko Kohno, Kohtaro Taniyama

著者情報

キーワード: Nebracetam, Ischemic hippocampal damage, Stroke-prone spontaneously hypertensive rat

ジャーナルフリー

1995 年 67 巻 1 号 p. 91-94

DOI https://doi.org/10.1254/jjp.67.91

詳細

抄録

The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CAI subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.

責任著者(Corresponding author)

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