A PHARMACOLOGICAL ASPECT ON GLUTAMIC ACID METABOLISM IN BRAIN
II. TRANSAMINATION AND ASSOCIATED OXIDATION REACTION CONCERNING α-KETOGLUTARIC ACID AND γ-AMINOBUTYRIC ACID IN BARIN
1957 年 7 巻 1 号 p. 6-15
詳細
1957 年 7 巻 1 号 p. 6-15
Nowaday, it is not clear how the energy obtained from the oxidative processes is coupling with the excitation of nerve, but if the stimulants may affect on the step forming the energy, the above aspect may be one of the recognizable things.
SUMMARY
1. The results indicating that γ-aminobutyrate may possibly be introduced into the TCA cycle via the transamination and associated oxidation were obtained.
2. The details of the transamination and associated oxidation of α-ketoglutarate andγ-aminobutyrate were observed.
3. An effect of β-hydroxy-γ-aminobutyrate on the transamination and associated oxidation of α-ketoglutarate and γ-aminobutyrate was studied.
4. The EEG of rabbit was recorded under the influence of β-hydroxy-γ-aminobutyrate administration.
5. A pharmacological aspect of excitation in brain was discussed.
