Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats

Kimihiro Yamashita; Yasufumi Kataoka; Mihoko N.-Nakashima; Yasuko S.-Yamashita; Hirofumi Tanabe; Hiroaki Araki; Masami Niwa; Kohtaro Taniyama

doi:10.1254/jjp.71.351

Kimihiro Yamashita, Yasufumi Kataoka, Mihoko N.-Nakashima, Yasuko S.-Yamashita, Hirofumi Tanabe, Hiroaki Araki, Masami Niwa, Kohtaro Taniyama

著者情報

キーワード: Ischemia-related delayed neuronal death, Prostacyclin analogue, Stroke-prone spontaneously hypertensive rat

ジャーナルフリー

1996 年 71 巻 4 号 p. 351-355

DOI https://doi.org/10.1254/jjp.71.351

詳細

抄録

TTC-909 is a newly developed isocarbacyclin methyl ester (TEI-9090) incorporated in lipid microspheres. The neuroprotective effect of TTC-909 was histologically examined in the pyramidal cell layer of the hippocampus CA1 subfield 7 days after transient forebrain ischemia using stroke-prone spontaneously hypertensive rats. TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemia-related delayed neuronal death. The blood pressure remained unchanged following TTC-909 administration. This finding suggests that TTC-909 has a neuroprotective action on ischemic delayed neuronal death in the hippocampus.

責任著者(Corresponding author)

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