Effect of 5, 6, 7, 8-Tetrahydroneopterin on Oxidative Modification of Low-Density Lipoprotein, and Its Uptake in the Macrophage-Like Cell Line J774

抄録

Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5, 6, 7, 8-tetrahydroneopterin (NPH₄) on Cu(II)-induced lipid peroxidation of LDL. NPH₄ significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein. Furthermore, NPH₄ suppressed the uptake of oxidized [₁₄C]oleyl-esterified LDL by the macrophage-like cell line J774. NPH₄ may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases.