Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Masayoshi Furushiro; Satoru Suzuki; Yoshiyuki Shishido; Masashi Sakai; Hideyuki Yamatoya; Satoshi Kudo; Shusuke Hashimoto; Teruo Yokokura

doi:10.1254/jjp.75.447

Masayoshi Furushiro, Satoru Suzuki, Yoshiyuki Shishido, Masashi Sakai, Hideyuki Yamatoya, Satoshi Kudo, Shusuke Hashimoto, Teruo Yokokura

著者情報

キーワード: Phosphatidylserine, Passive avoidance, Scopolamine

ジャーナルフリー

1997 年 75 巻 4 号 p. 447-450

DOI https://doi.org/10.1254/jjp.75.447

詳細

抄録

Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

責任著者(Corresponding author)

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