血管分岐の流体力学的研究

-末梢血管床への血液供給におよぼす効果-

抄録

This study is concerned with hemodynamics of branching flows in the cerebral circulation, which is important in pathogenesis of regional ischemic lesion or hypertensive intracerebral hemorrhage occurring preferentially in the basal ganglia. A series of measurements of energy-loss coefficients at branching sites under laminar steady flow have been conducted in model branches having various geometries. Furthermore, the effect of branching on blood supply to its distal area is described using a lumped-parameter model which was constructed according to the measurement of the vascular architecture in the basal ganglia.
It is emphasized that, in circulation in vivo, the branching loss is important where a small artery divides off from a large trunk. It is also indicated that the effect of such branchings may become more significant when the autoreguratory mechanism is abolished under pathological conditions such as CO-poisoning. (J. Jpn. Soc. Biorheol., 1 (2), 77~85, 1987).