糖尿病における尿細管機能ことにTm PAHとTm G,およびGlucose Titration Curveについて

抄録

RPF, GFR together with TmG were measured 24 times, and TmPAH was measured 21 times in altogether 47 cases of diabetes.Glucose titration curves were determined in 2 cases of mild diabetes.Besides, renal function was observed in 3 cases of renal diabetes.1) There were many servere cases in the group whose GFR was normal or in the upper limits of normal. As Tm G and TmPAI were either normal or in the lower limits of normal in this group, GFR/TmG became increased and GFR/Tm PAx were in the upper limits of normal.2) There were more cases with milder symptoms in the group whose GFR was in the lower limits of normal. Tm value were within normal limits. GFR/Tm G, GFR/Tm PAR were also normal.3) In the diabetic cases with slightly decreased GFR, GFR/Tm G and GFR/Tm PAR were normal.4) There were relatively larger number of cases of diabetes with long histories among those whose GFR was more than moderately decreased. Although the values of their fasting blood sugar were variant, the amount of urinary sugar output was less than 20 grams per day, GFR/ Tm G and GFR/TmPAH were only slightly decreased.5) All of those who had old age, hypertension, albuminuria, changes in fundus of the eye espe-cially with changes of K. W. III and upward, the complication of myocardial damage and long histories of diabetes showed decreased renal function. In many of the above cases, the urine sugar was less than 20 grams per day. GFR/Tmn and GFR/TmPAH were within normal limits.6) In three cases of renal diabetes, RPF and GFR were normal, whereas Tm G values were all markedly decreased.7) Glucose titration curves were determined in 2 cases of mild diabetes indicating the results that tmg was equal to 0.6……1.7 times Tm G and was within normal limits.