An Electrophysiological Study of the Effect of L-Potassium Aspartate on the Renal Tubular Function of the Rat

The Effect of L-Potassium Aspartate on Renal Tubular Potential (II)

Abstract

In an attempt to examine the physiological effect of L-potassium aspartate (K-aspartate) on the kidney with special reference to the action of aspartic acid, the intracellular potential of renal tubule of the rat was measured with lapse of time after intravenous injection of K-aspartate. Similar measurment was made with the rat administered by the mixture of KCl and L-aspartic acid which contain the same amount of K and aspartic acid radical with K-aspartate. The intracellular potential falls in either case, while the fall by K-aspartate is deeper than that by the mixture of KCl and L-aspartic acid. Therefore, it is reasonable to presume that the physiological effect of K-aspartate is not a sum of KCl effect and aspartic acid radical, but should be explained with reference to a specific physicochemical structure of the salt.