Abstract
1. Periodic acid silver methenamine staining for electron microscopy is considered to be a fairly useful technique for glycoprotein detection and a most valuable method for demonstration of histochemical changes at ultractructure level.2. Control and nephrotic kidneys of human and rat are studied by this method. The formation of the basement membrane in the glomeruli of normal and pathological conditions, are apparently performed by the epithelial cell.3. The mesangium plays an important role in turn-over of the basement membrane, under the control condition and experimental nephritis.4. It is likely that the change of stainings in lipoid nephrosis and aminonucleoside nephrosis is related to the histochemical changes of the basement membrane.5. It is assumed that membranous nephropathy might be induced by the percipitation of deposit in the glomerular basement membrane.
