抄録
Intermittent peritonecl dialysis has been widely used in the treatment of acute and choronic renal failure. However, there are seen occasionally some disadventags, among which loss of protein and peritoneal inflammation are particularly important. This study was attemptemd to clarify the change of peritoneal permeability of protein by intermittent peritoneal dialysis. Serum and concentrated samples of dialysis fluid were examined by paper electrophoresis, agr-immunoelectrophoresis and immunodiffusion technic for three individual protein i. e., albumin, transferrin and IgG. The results are follows : 1) Protein depletion is a serious problem when dialysis is required for long periods. Inflammatien of peritoneum does always increase the excretion of protein in to the dialysis fluid, that induces a steady decrease of the serum protein. As a high protein diet is not enough to raise the serum level of protein, the intravenous supply of protein is really necessary for resolving this problem. 2) Low molecular protein like albumin can pass through the normal peritoneum, but high molecular protein like IgG cannot be permeable to it. 3) Physical and chemical stimuli and/or bacterial infection induce the inflammation of peritoneum at early time of dialysis, characterized by ascites, change of peritoneal permeability of protein or even high molecular protein. In long-term dialysis, high molecular protein like IgG becomes permeable to the peritoneum, so that the serum protein may decrease more than in shortterm dialysis.
