Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in various hypertensive subjects

Abstract

We determined plasma dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulfate (DHA-S) levels in man, using technique of radioimmunoassay by the method of Nieschlag et al. Plasma DHA level increased at 2 hours after the intramuscular injection of ACTH (Cortrosyn), but plasma DHA-S level was not affected. Normal male and female subjects from 21 to 30 yrs. had higher plasma DHA and DHA-S levels than those of male and female subjects of other generations. And the high DHA and DHA-S levels were noted in normal male subjects from 21 to 30 yrs., compared to those of female subjects from 21 to 30 yrs. Plasma DHA and DHA-S levels of patients with essential hypertension were higher than those of normotensive patients in mean value. But there were similiarly no statistic diffecrences between the two groups of patients, as indicated by Shao et al.