1980 Volume 22 Issue 4 Pages 393-399
In our population of 99 patients with SLE, 5 patients have developed avasculsr bone necrosis(AN).And in 230 patients with nephrotic syndrome wthout SLE, one has developed AN. All patients with AN received corticosteroids prior to the onset of AN, however, patterns of corticosteroid therapy have no relationship to the development of AN. There is significant higher incidence of developing AN in the patients with SLE (5%) as compared with the patients with nephrotic syndrome (0.44%), although patterns of corticosteroid therapy in those two control groups are similar. These findings suggest that SLE has certain etiologic factors to develop AN. Among the possible etiologic factors in SLE, vasculitis has been the mose considerable, and the hypercoagulability has been thought to be aggravated by the adminietration of corticosteroids. However, in our cases with SLE, signs of vasculopathy are less remarkable in those with AN than in those without AN, furtherr more one case with SLE who had received anticoagulant agents prior to the onset of AN has also developed AN.The pathogenesis of AN is to be discussed more further.
