The Study of Impaired Reducing Power in Chronic Renal Failure Patients with Emphasis on Red Blood cells and lipoperoxide

Abstract

We investigated redox balance in chronic renal failure patients by ascorbate-cyanide test and by measuring G-6-PDIH activity of red blood cells and serum lipoperoxide. The patient's reducing power is impaired slightly or is latent before the institution of hemodialysis but aggravates and becomes manifestive with hemodialysis therapy. The influence of exogenous oxidant (free chlorine in tap water) is remarkable in dialyzed patients and the reducing power decreases furthermore. As the concentrations of serum vitamin E and A which are antioxidants are dependent on carrier protein concentrations in blood, their concentrations in tissue are unclear. Globin conformation should be investigated to clarify the cause of impaired reducing power of red blood cells in chronic renal faiiure.