抄録
Thirty one patients, under maintenance hemodialysis 15 male and 16 female, aged from 19 to 62 years old, were studied with special referrence to biochemical parameters concerning renal osteodystrophy. Based upon duration of hemodiallysis, 31 patients were categorized in three groups as follows, 8 patients having duration less than 1 year, 8 pateints less than 2 years and 15 patients more than 2 years. Serum Al-P3 activity not only well correlate with serum Al-P activity but also linealy arised with increasing of duration of hemodialysis, i.e., 2.6±1.4K-A in group less than 1 year, 5.7±5.3K-A in group less than 2 years and 9.4± 10.2K-A in group more than 2 years. Serum i-PTH value was elavated as high as 3.6±3.0ng/ml in all patients studied and high value was found in patient of longer hemodialysis duration, i.e., 2.5±2.3ng/ml in 16 patients less than 2 years and 4.8±2.6ng/ml in 15 patients more than 2 years. Decrease in serum Ca++ value was not remarkable in most patients, but many of those having somewhat lower value of serum Ca++ was likely to have higher level not only in serum Al-P3 activity but also in serum i-PTH value, too. Concerning serum pyrophosphatase activity, we could find significant higher value of 9.0±3.8nmol/min/ml in patients compared to 5.6±0.8nmol/min/ml in control normal subjects (n=5). On the othere hand, we could not any difference in serum HP level in patients against normall subjects, i.e., 6.2±5.2mg/l in patients compared to 6.1±2.0mg/l in control normal subjects (n=5). As to correlationship among these biochemical index parameter, correlation between pyrophospatase and i-PTH (r=0.658 p<0.01). and between Al-P3 and i-PTH (r=0.724 p<0.01), were noted in the sense of estimation responsibility of both osteoblast and osteoclast against PTH secretion.
