Abstract
The role of calcium-regulating hormones on the development of ROD in chronic hemodialysis patients was examined. On 48 uremic patients with or without ROD (P-ROD or P-0), the concentration of parathormone (PTH), calcitonin (CT) and 25-hydroxy-cholecalcif erol (25-OH-D3) in plasma, as well as the other factors were determined. The following results were obtained: 1) The concentrations of PTH and CT in plasma and Ca++ in whole blood on P-ROD were heigher than the corresponding values on P-0. The plasma 25-OH-D3 concentrations in both patients groups were lower than that in normal subjects 2) No significant ocrrelations among each measured concentration of these calcium-regulating hormones (PTH, CT and 25-OH-D3) were found. 3) By hemodialysis, the plasma PTH concentration on P-0 markedly decreased, but in P-ROD, no change was observed. The plasma 25-OH-D3 concentration and the CT concentration increased significantly in both patients groups 4) In the patients treated with 1α-D3, plasma PTH concentration decreased, but the treatment with D2 was ineffective 5) By rapid calcium infusion, there was a decrease in plasma PTH concentration and an increase in plasma CT concentration in P-0, while the both concentrations remained the same in P-ROD. These results suggest that the patients on chronic hemodialysis suffer from secondary hyperpa-rathyroidism, especially that P-ROD suffer from tertiary hyperparathyroidism.
