Two cases of IgA nephropathy associated with Buerger's disease (Thromboangiitis obliterans)

Abstract

Buerger's diseae, predominantly in young and middle-aged male smokers, is a non-specific inflammation of small and medium-sized arteries with thrombus obliteration and without arteriosclerotic change. Renal biopsy specimens from two cases of Buerger's disease showed unexpectedly mild mesangial proliferatve GN and predominant IgA deposition in mesangium, morphologically identical to primary IgA nephropathy. One was a 36-year-old man, the other was a 47-yearr old man. Both smoked heavily. They had never been pointed out urine abnormalities o Proteinuria and microscopic hemam tuna were observed in both cases first at the almost same time when Buerger's disease appeared clinically. It is considered too hasty to decide promptly that these two diseases are mere complica-tionsm These cases suggest heterogeneity of IgA nephropathy.