抄録
A study was made on effects of various drugs on the changes in renal circulation by cold pressor test which was performed to clarify the regulatory mechanism of renal circulation under stress. Cold pressor test (dry ice methoe) was performed on adult mongrel dogs. The effects of the cold pressor test on the blood pressure and renal clearance were studied as control experiment, and following intravenous administration of hexamethonium (5mg/kg of body weight), reserpine (0.5 mg/kg), chlorpromazine (5 mg/kg), 1-hydrazinophthalazine (4 mg/kg), veratrum (0.025mg/kg) and methylhexabital (30mg/kg), cold pressor test was again performed on the animals a week later to review the previous findings. The results were as follows: During the cold pressor test, the dogs that were not administered with the drugs showed an increase in blood pressure, a decrease in renal plasma flow, glomerular filtration rate and an increase in tolal renal vescular resistance. 2) To this effect of the cold pressor test, definite inhibition was noted upon administration of C6, moderate inhibition seen in the case of chlorpromazine and the tendency of slight inhibition was recorded when reserpine was used. 3) Hydrazinophthalazine, veratrum and methylhexabital showed no significant inhibition to the changes in renal clearance values induced by cold pressor test. From the above findings that the effect of the cold pressor test was inhibited by drugs which block the sympathetic system it was considered that the sympathetic system plays primary an important role on the regulation of renal circulation under stress and, further from the results on methylhexabital, no definite relation was obserued between the reticular formation and reactive system of cold pressor test in the case of given dosage.
