日本腎臓学会誌
Online ISSN : 1884-0728
Print ISSN : 0385-2385
ISSN-L : 0385-2385
本態性高血圧症及び瀰漫性糸球体腎炎における脳,心,大動脈の変化について
末永 守
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1961 年 3 巻 4 号 p. 519-542

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The author studied pathohistolo, gically the brain, heart, kidney and aorta of 37 cases with essen tial hypertension and/or arteriosclerosis and 9 case of diffuse glomerulonephritis. The patients of the former group are as follows: cerebral hemorrhage 10, encephalomalacia 3, and myocardial infarction 2, coronary arteriosclerosis 3, heart failure 2, malignant nephrosclerosis 'l, benign nephrosclerosis 10, and arterioscler otic contracted kidney 3. The results obtained are summarized, as follows: The vascular trees of the kidney, brain, and heart were divided into three segments : arteriole, medium-sized and large arteries. In essential hypertension and arteriosclerosis, the histologic changes in the corresponding segments in these organs were essentially the same. The localization of the main change seems to be decided by the tempo of progression of the diseases and by the age of the patients. When the patient is young and the progression of the diseases was rapid, the change was predominant in the kidney. When the age is above 40 and the progression is relatively slow, the main change was found in the brain. Sclerosis of coronary arteries began to develop in younger patients and progressed slowly. It was only in older patients that coronary arteriosclerosis pathohistologically induced myocardial damage, unless the heart was rapidly enlarged. In diffuse glomerulonephritis, the vascular changes were localized in the arterioles and interlobular arteries of the kidney. The changes were milder than in nephrhsclerosis.

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